Fear and Loathing, a Rat Flu Odyssey

[KQ]

Dangerous news:

Sources believe coronavirus originated in Wuhan lab as part of China's efforts to compete with US

https://www.foxnews.com/politics/cor...ete-us-sources

Qanon has been on that for months

[Lvovsky]

[4matic]

Qanon has been on that for months

Lots of sources have been "on it" but making that the page one headline on a major news outlet is different.

[muted]

RE: Austin or anyone else here. Maybe lighten up on them a bit. This is a great place to vent or float your 1/2 baked theories or ideas or even fears. Give a little bit. (sorry listening to Supertramp channel on Pandora.

Yes. And a lot of you guys ripping on Austin may have more opinions that I agree with but I’d rather have a beer with Austin, you guys are way too internet serious.

[Mofro261]

Mofro, please correct me if I'm wrong: the SARS vaccine work gave us a template for a coronavirus vaccine, and if I understand it correctly the RNA information is being plugged into the template. (I realize this is grossly oversimplified; I prefer things I can cut out to biochemistry). That process is relatively quick, but there's no way to know if the vaccine will work (or if it will kill people) without giving it to people. Unlike a treatment for Covid19, where you can see results within a week or 2. it takes a long time to test a vaccine--you have to give it to a lot of people and then wait a long time to see if fewer of them get sick than people who didn't get the vaccine. A significant number of people have to be actually exposed to the virus before we know if the vaccine works. (The yellow fever research was done by having volunteers, including the researcher Dr. Walter Reed letting themselves be bitten by mosquitoes in Panama--they got sick, proving that Aedes Aegyptii was the vector. Nowadays we can't deliberately expose volunteers to Covid19. )

The point being that you can't make a vaccine for a virus that doesn't exist yet. You have to have antigenic material from the virus, unless you are very lucky and the new virus is antigenically similar enough to an existing virus--like smallpox and cowpox.

Sars1 and Sars2 are quite similar actually, 75-80% identical. With that knowledge and a sequenced genome, groups/companies were able to devise vaccines based on the Sars2 viral RNA sequence that do not require an antigen like say inactivated virus or a protein extract, to immunize. The RNA provides a template for replication of a defined antigen within the host vaccinee- you use your own body's cells to generate the protein ( most always Spike for Sars1/ 2) and then allow the immune system to respond and make antibodies to it in situ.

It's not a new concept, but AFAIK no vaccines have yet to be approved by this approach. Thus other groups are working on more traditional vaccines based on inactivated virus grown iin vitro in cells, or a protein subunit approach. Because the latter approaches reuqire time to generate the materials, it takes a little longer to get into safety, and then efficacy trials. Normally it is the efficacy trials that require the most time and rigor. Then there is process development/ scale up etc. but under an accelerated approach this is occuring simulatenously with safety data, so that multiple aproaches will be compared to see what provides the greatest benefit.

Why it might and should work, we can look to those people who have been infected and determine if their convalescent plasma contains antibodies that neutralize the virus, which is being tried as a therapeutic approach right now. If recovered patients have these antibodies they should be protected from reinfection and devising strategies to generate these types of antibodies should be possible by vaccination.

What we don't want to happen is make a vaccine that actually makes things worse. I won't get into the heavy details of Antibody Dependant Enhancement of infection where generation of Ab's to vaccination/infection are generated that are not neutralizing, but instead bind virus and enhance uptake into cells by nonviral-receptor mediated antibodyopsonization upon re-infection with a related strain (google Dengvaxia- dengue fever is notorious for this).

[St. Jerry]

I'd send him some cash. Can I get an address?

I'd be happy to throw some $ his way but I want him drug tested first.
Want hand-outs from me? Must be drug free. (it rhymes).

[riser4]

lol, well played

I'm a man without a (ski) home. People give me shit for never making tele turns, and other people give me shit for being a tele skier.

I can't give you shit for both?

[Lvovsky]

Speaking of $$. The us Fed checks: are they an “advance” on our 2020 tax refund (for overpayment)? I’m sure this is somewhere up thread. I can’t keep up. I still have a job, working harder than ever but with 10% less pay, 10% reduction in all other benefits, and 20% less PTO accrual. Not complaining and hoping I don’t get sick. Wife took big income hit.

They are tax credit for 2020; will reduce your taxable income in 2020

from https://taxfoundation.org/federal-co...ill-cares-act/

What exactly are the recovery rebates?

The recovery rebates (Economic Impact Payments) are refundable tax credits. This means that the rebate decreases a taxpayer’s tax liability dollar-for-dollar, and the credit can be refunded to a taxpayer if they have no tax liability to offset.
The rebates are tax credits that will be applied to 2020 tax returns, but are advanced to taxpayers now based on their 2019 or 2018 adjusted gross income (AGI). The credit will be applied to 2020 tax returns using 2020’s AGI next spring, and taxpayers will receive the difference of the credit if it is in their favor.
For example, if a single taxpayer with no children made $200,000 in 2019, they would not receive an advance rebate based on their 2019 income. However, if they make $35,000 in 2020, they will receive a $1,200 refundable tax credit on their 2020 tax return. But in reverse, if a taxpayer had a $35,000 AGI in 2019 but has $200,000 AGI in 2020, they would receive a $1,200 rebate now and would not have to pay it back on their 2020 tax return.

[schuss]

Are you serious? Austin hasn't even asked for help let alone called anyone a libtard, as far as I can tell, ever.

There is some grade A gaslighting going on right now in this thread.

I was trying to describe the general feeling many of us get which is leading to some of the reactions here. A lot of us have been eating constant baiting from others for a long time, so it's easy to get frustrated. Shit is happening, and I don't actually want it to happen to anyone, but opening shit up is going to help no one.
I'm now up to 6 people I know who have had serious symptoms and recovered (thankfully). None could get tested because there are no tests except on your way into the ICU. Everyone I know is either laid off or on edge from dealing with small kids 24/7 while trying to work remotely, yet there is zero help from those that could but are too damn selfish to do so. Fuck selfish people and fuck these current protests. If shit opens, at least one of my parents will likely die from this and probably friends and co-workers.
Let's not do that.

[Benny Profane]

Lots of sources have been "on it" but making that the page one headline on a major news outlet is different.

Fox is not news.

[BC.]

Fox is not news.

And the others are? (CNN, ABC, etc...)

[KQ]

FYI for those who think this is a disease that attacks the old:

COVID-19 cases continue to rise in WW County

April 15, 2020 5:06 pm
WALLA WALLA – There are now 26 positive COVID-19 cases in Walla Walla County. While the number of positive cases has climbed, the Walla Walla County Department of Community Health reports that seven of those patients have now recovered.

The latest numbers show 1,086 tests have been submitted, 1,060 tests were negative, 26 were positive. Of the 26 positive cases, 13 reside in Walla Walla, seven reside in the Burbank/Wallula area, five reside in College Place, and one lives in Prescott.

The positive cases are equally divided between men and women. One person is under the age of 20, nine are between 20 and 39, 10 are aged 40 to 59, and six are between 60 and 79. None are 80 or older.

[Lvovsky]

Wow. Lawn seed and hair color.

Oblivious to the threat that has killed 31,800 of their countrymen in four weeks and keeps killing... it’s just sad.

[XXX-er]

The Rules:

.

this isnt Nam ... there are rules

[Lvovsky]

You're right. In fact, that's literally exactly what one hiring manager told me her concern about me was. I convinced her that I was happy to work and would love to join the team (for a night position doing factory work). Got through that process and then the plant got shut down til further notice. Faaaaaaaack...

Sent from my Pixel 3 using TGR Forums mobile app

I’m sorry there is no social safety net that can support you during these difficult times.

[Rideski]

Nursing homes are urgently hiring people not scared of rat flu.

https://www.nytimes.com/2020/04/15/n...me-deaths.html

[hutash]

Dangerous news:

Sources believe coronavirus originated in Wuhan lab as part of China's efforts to compete with US

https://www.foxnews.com/politics/cor...ete-us-sources

Who needs Russian disinformation when you have Fox News?

[KenJongIll]

FYI for those who think this is a disease that attacks the old:

COVID-19 cases continue to rise in WW County

April 15, 2020 5:06 pm
WALLA WALLA – There are now 26 positive COVID-19 cases in Walla Walla County. While the number of positive cases has climbed, the Walla Walla County Department of Community Health reports that seven of those patients have now recovered.

The latest numbers show 1,086 tests have been submitted, 1,060 tests were negative, 26 were positive. Of the 26 positive cases, 13 reside in Walla Walla, seven reside in the Burbank/Wallula area, five reside in College Place, and one lives in Prescott.

The positive cases are equally divided between men and women. One person is under the age of 20, nine are between 20 and 39, 10 are aged 40 to 59, and six are between 60 and 79. None are 80 or older.

Just to emphasize this...from personal experience, my wife’s first cousin, mid 40s, good shape, small,town Dr., was hospitalized for several days.

[iceman]

Just to emphasize this...from personal experience, my wife’s first cousin, mid 40s, good shape, small,town Dr., was hospitalized for several days.

Is she in WW county?

[hutash]

Just for shits and giggles I read some of the comments section of the Fox link. Holy shit! AR and Austin are stable geniuses compared to those nutters. Some nice retorts, though.

[Lvovsky]

i think its a good idea also, one of the cool things about this place is when mags step up to help mags (actually it is THE coolest part about this oddball collection of dentists). Count me in.

Create a charity “Dentists helping Dentists” and you’ll get some nice donations from the actual but unsuspecting dentists. Don’t use word maggots in the brochure.

[old goat]

They are tax credit for 2020; will reduce your taxable income in 2020

from https://taxfoundation.org/federal-co...ill-cares-act/

I've read that over and over and as best as I can figure what they're saying is--it's a 2020 tax credit but instead of deducting the amount from your tax for 2020 they give you a check now and when you pay your 2020 taxes you pay the normal amount that would be due. Which for practical purposes means that you get a check now with no consequences as far as future taxes. I haven't seen another source for this explanation. Perhaps there was a technical reason the bill was written that way--maybe as a way of getting the IRS to do the distribution--but nobody has bothered to tell people about the tax credit angle because it has no practical meaning.

Mofro--are people still hypothesizing that the severe lung reactions are a hyperimmune response rather than direct result of the viral infection? If that were the case obviously a vaccine could be perilous. Or has that hypothesis been discarded?

[MakersTeleMark]

A big reason is that it won't be taxable as income so you get the whole nut.

[Rideski]

Who needs Russian disinformation when you have Fox News?

Story about Chinese misinformation and disappeared journalists.
Spoiler, nothing about the lab angle.

[old goat]

A big reason is that it won't be taxable as income so you get the whole nut.

I guess they could have just said we're giving you a check and it's not taxable but that would be too easy.