Please get a flu vaccine

[KQ]

Because of the t shirts I often see with pictures of bacon and the word carnivore on them?

you see t-shirts that say something ergo everyone but you is whatever it says?

[babybear]

let’s generalize everyone bc of some redneck’s tshirt
that’s some stable logic

[Mofro261]

The problem is genetic drift in the flu virus (mutation is not quite correct). This makes it impossible to have a “universal” vaccine.

The other viruses arent as prone to this so can be globally targeted.


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In animal challenge experiments, groups have been able to get cross-protection by increasing the breadth of the antibody response through the use of targeted adjuvants. In essence, certain parts of the viral coat proteins are subject to more genetic dirft than others, but tweaking the host immune response with immunostimulants can broaden the antibody response to include more conserved regions that are cross-reactive and neutralizing. The big problem with many of these immune-broadening compounds is increased reactogenicity- an over stimulation can also lead to a "cytokine storm" which creates a hard path for regulatory approval from a safety perspective. Also, the ferret and mice models do truly capture the human immune response, so some of the compounds work really well in animals but are less favorable at generating a similar response in humans.

[TheSilverSurfer]

you see t-shirts that say something ergo everyone but you is whatever it says?

Don't be ridiculous. There are many threads here where being a carnivore is a joke. And then of course there's the whole bacon thing.

[bagtagley]

I can wear a Lady Gaga meat suit, I’m still an Omnivore. So are you.

[MagnificentUnicorn]

I'm not the one being an asshole. I've calmly explained my position and backed it up.

In response I've been called a fucking idiot and a moron, and my wife has been attacked.

Who's the asshole?

Look in the mirror?

[iceman]

...the ferret and mice models do truly capture the human immune response...

Was there supposed to be a "not" in there?

[MagnificentUnicorn]

Was there supposed to be a "not" in there?

Yeah, and I think I'd listen to Mofro if we're having a conversation about vaccines here.

[Mofro261]

Was there supposed to be a "not" in there?

oops, yes.

[Danno]

That's the awesome and scary thing about this place, it's hard to bullshit on very technical topics here, because there's bound to be a maggot who is actually an expert in that shit.

[adrenalated]

it's hard to bullshit on very technical topics here

Although that never really stopped anyone.

[Danno]

Although that never really stopped anyone.

Dentists are a thickheaded group.

[summit]

Tnx for that post Mofro

[Harry]

This whole thing reads like a Chemtrails thread.

FIFY.

I can't believe how stupid the anti-vax crowd is. No surprise that the head anti-Vaxer in this thread was a Ron Paul devotee in 2012 and then a BernieBro in 2016...

[old goat]

On On Point on NPR this morning an expert said NIH spends 1 billion a year on HIV vaccines (a good thing) but only 31 million on flu vaccine so don't expect a universal flu vaccine anytime soon.

Edit...link to article he was probably referencing.

https://www.google.com/amp/www.chica...story,amp.html

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According to Dr. Fauci--head of the Nat'l Inst of Allergy and Infectious Disease, which is the branch of the NIH that funds vaccine research, influenza is now the number one priority. Seems appropriate, according to the CDC the influenza death toll ranges from 3,300 to 49,000 per year. AIDS kills about 6000/year, although it also causes life long morbidity and the need for very expensive meds. What the change in priority will mean in actual funding remains to be seen.

For those who didn't understand what mofro said--the part of the flu virus that provokes a strong immune respons changes, so you can't make a universal vaccine effective against that part of the virus. There is a part of the virus that doesn't change, but it also doesn't provoke a strong immune response. The challenge is to make that part of the virus provoke a stronger response in the human. This has been accomplished in lab animals but not tried on humans yet.

[babybear]

welp pretty sure i have the flu. second day spent on the couch and haven’t felt this sick in many yrs.
I didn’t get a flu shot basically bc of laziness so it’s my own fault.
andrew got a shot tho so we’re somewhat interested to see if it works for him or if he comes down with it too.

[mcski]

Bummer. GWS

[Danno]

a Ron Paul devotee in 2012 and then a BernieBro in 2016...

How does that work?

[Danno]

Bummer b-bear.

[mcski]

How does that work?

Same as some of the tards that voted orange douche because bernie was out of the race.

[Skidog]

In animal challenge experiments, groups have been able to get cross-protection by increasing the breadth of the antibody response through the use of targeted adjuvants. In essence, certain parts of the viral coat proteins are subject to more genetic dirft than others, but tweaking the host immune response with immunostimulants can broaden the antibody response to include more conserved regions that are cross-reactive and neutralizing. The big problem with many of these immune-broadening compounds is increased reactogenicity- an over stimulation can also lead to a "cytokine storm" which creates a hard path for regulatory approval from a safety perspective. Also, the ferret and mice models do truly capture the human immune response, so some of the compounds work really well in animals but are less favorable at generating a similar response in humans.

barely understand any of this, but sometimes the smarts in this place amaze me...friggin dentists...

[glademaster]

welp pretty sure i have the flu. second day spent on the couch and haven’t felt this sick in many yrs.
I didn’t get a flu shot basically bc of laziness so it’s my own fault.
andrew got a shot tho so we’re somewhat interested to see if it works for him or if he comes down with it too.

TamiFlu, ASAP. Beg, steal or borrow to get it and start taking it today.

I always make sure to have a big ass stash of TamiFlu and Relenza in the house starting each fall. Fresh scripts every year.

[TheSilverSurfer]

How does that work?

That's what happens when opposition to war and the industrial military complex is your number one issue.

[bodywhomper]

TamiFlu, ASAP. Beg, steal or borrow to get it and start taking it today.

curious on the over/under of tamiflu. ease to get, risks, etc.

at the drug store a few days ago and there was a VERY sick woman picking some up for herself. i used my clothes that evening as kindling in my stove.

[glademaster]

I am sure that there are people here who can speak more technically about it, but from my understanding, if she was already that sick, it will be of limited use for her. The key is to start taking at as soon as possible once you start to feel the onset of symptoms, which is why I make a point of always having it on hand, in the house, at the start of every flu season.

I have relations who can can prescribe it, so I never have any issue getting it prior to being sick. I imagine it shouldn't be too hard to track down.