Fear and Loathing, a Rat Flu Odyssey

[highangle]

Speaking of immunity, recent research suggests there's crossreactive immunity from other coronaviruses which might explain why there's so many mild or asymptomatic cases, and also suggests vaccines that target the CD4+ T cell responses could work:

There has been a huge amount of uncertainty about immunity to SARS2—both in the context of COVID19 disease pathogenesis and in the context of how to develop a good vaccine.

In the study, 100% of COVID-19 cases made antibodies. 100% of COVID-19 cases made CD4 T cells. 70% of COVID-19 cases made measurable CD8 T cells. We believe these findings are good news, and consistent with normal antiviral immunity.

CD4+ T cell responses to spike, the main target of most vaccine efforts, were robust and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers. Again, good news.

Additionally, any potential for crossreactive immunity from other coronaviruses has been predicted by epidemiologists to have significant implications for the pandemic going forwards. We detected SARS-CoV-2-reactive CD4+ T cells in ~50% of unexposed individuals.

Detecting SARS2-reactive T cells in ~50% of unexposed people suggests cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and SARS-CoV-2. This might influence susceptibility to COVID-19 disease.

https://www.cell.com/cell/fulltext/S...674(20)30610-3

https://rattibha.com/thread/1261052353773363200?lang=en

I picked up a head cold in early Feburary - first cold in at least a decade. Though it was the "Sakhalin Sniffle", since I was there in late January. Was still blowing my nose when I got a call from family saying 'this Coronavirus thing is real and may blow up, get prepped and keep your eye on the news'

Heck no, I ain't gettin' tested for antibodies. Risky. Too many people directly dependent upon me for their livelihoods.

[PB]

...
We are no further today than we were with the 1918 Spanish flu outbreak with regard to operating businesses etc than we were when this first started. .....

FIFY. ...... Sadly

[jono]

Respectfully disagree with your F.

It is the fundamental rift, in part because most people don't really understand what it means to think in terms of science theories.

This "because" points to a different cause than the one you cited. Maybe you could show correlation? But even if you did, some level of correlation does not make one thing a dependant function of the other. Maybe it feels like it is in your mind. Your mind is a somewhat small sample and the simple test of that hypothesis would be checking if others see it differently. Others do.

[Buster Highmen]

This "because" points to a different cause than the one you cited.

No, it explains it.

Maybe you could show correlation? But even if you did, some level of correlation does not make one thing a dependant function of the other. Maybe it feels like it is in your mind. Your mind is a somewhat small sample and the simple test of that hypothesis would be checking if others see it differently. Others do.

There is sufficient data to support the claim. And no correlations is not causation, jeez.

Most people, especially the Christian Church, saw a heliocentric theory differently too.

[highangle]

Chris Hitchens hit the nail on the head when he partitioned the world into Theists and Nontheists. That is where the discord and divisions lie.

Once they get you to believe, truly believe, that a Magic Sky Lord made the universe in six days and reads your innermost thoughts...Well, the rest is a lot easier.

[ron johnson]

It would be helpful if the subset of folk(s) here would stop the "lockdown" rhetoric. There are very few instances of crude shotgun blast lockdowns in America. It's a minority of people persisting with the same politically motivated terminology.

What we have is individual and geographic variations of social distancing, personal hygiene, self isolation, contact tracing, household quarantine, shelter the elderly, and masks along with varying limitations on crowd sizes and certain types of business.

If people want to frame this as a binary choice — between endless lockdown or reckless reopening — then it needs to be understood for what it is: the failure of our political leaders to create a safer, middle path.

What?

We can't use the term lockdown, that is used everywhere, and obviously refers to the gov't mandated restrictions on what people can and can't do?

Lobby Heroes of the Lockdown
https://www.nytimes.com/2020/05/15/n...ntial-nyc.html

Streets Should Be Car-Free During Lockdown. And After.
https://www.nytimes.com/2020/05/01/nyregion/coronavirus-streets-closed-nyc.html

Is It Safe to Come Out of Lockdown? Check the Sewer
https://www.nytimes.com/2020/05/01/s...-lockdown.html

Lockdowns are ending. We need to stay ready for the virus to surge.
https://www.washingtonpost.com/outlo...n-preparation/

Life in lockdown is testing parents’ bandwidth, but there are ways to protect your mental energy
https://www.washingtonpost.com/lifes...mental-energy/

Etc.

The fact that there are optimistic trends in America is because the "Darwinian natural selection" crowd are in the minority. Most Americans are doing what they can to protect their families and communities, and that's what's extraordinary.

It's extraordinary that people are doing what they can to protect their families and communities? It's extraordinary that people don't need gov't to tell them how to protect themselves? You must have an exceptionally low opinion of humans.

"Darwinian natural selection" crowd is a gross mis-characterization.

[ron johnson]

fuck off ron.

edit: you're no mag that is for sure.

Never had an interaction with this person.

Nice community you guys have here.

[muted]

Never had an interaction with this person.

Nice community you guys have here.

fuck off ron.

[Flyoverland Captive]

Ruh-roh...


https://www.google.com/amp/s/www.pol...navirus-261873

[skifishbum]

Suppose this has always been in the back of my mind but it really hit home this morning -

We are no further today than we were when this first started with regard to operating businesses etc than we were when this first started.

With no therapy or vaccine nothing has changed and all these people rushing out without masks or social distancing is going to start the ball rolling all over again but then maybe that's what needs to happen. I just don't know anymore.

/depressing thoughts

im in the garden today and fished yesterday they are my optimistic endeavors
even though I didn't "git em or do much catching the rhythmic groove of the oars moving the boat or the muscle memory timing of the hauls to load the whippy sticks and send it in hopes of positive rewards are my happy places
the john prine pandora station plays as much todd snider as john
buster thinks on levels I aint never gonna gits him and ice can talk deepness that my kiddie pool mind struggles to float in
withs or withouts mind alteration

[KQ]

Ugh. This is why we are doomed and I fear there will be no way to correct all the damage these people are doing even if we get someone else in the WH. The die is cast....... those who believe this virus is political will never come around to seeing it any other way and will resist until they are put on a ventilator and even then I'm sure they will blame it all on someone else they hate.

Eric Trump says coronavirus is a ploy to stop his father's campaign rallies and will 'magically' disappear after election day

‘Great People’: Trump Hails Maskless Protesters Who Bullied And Insulted Reporter

[Self Jupiter]

So it’s our job to make you likable, Ronny?

[XXX-er]

I picked up a head cold in early Feburary - first cold in at least a decade. Though it was the "Sakhalin Sniffle", since I was there in late January. Was still blowing my nose when I got a call from family saying 'this Coronavirus thing is real and may blow up, get prepped and keep your eye on the news'

Heck no, I ain't gettin' tested for antibodies. Risky. Too many people directly dependent upon me for their livelihoods.

https://vancouversun.com/opinion/dr-...-our-pandemic/

"It’s still important to remember not everybody needs a test and the tests we have are not perfect. If someone tests negative, it may mean they are too early in the illness for the test to detect it yet — a false negative. "

from our top MD in BC ^^ so according to Bloomberg she has the lowest death stats in Narth America so there is not much testing going on up here, about the chinese intention to test an entire city of 11 million she thot it would thro a lot of false test results

https://www.bloomberg.com/news/artic...kOyoOyP15eUPC0

and a pretty serious fetish for funky shoes
https://www.victoriabuzz.com/2020/04...rences-photos/

[KQ]

im in the garden today and fished yesterday they are my optimistic endeavors
even though I didn't "git em or do much catching the rhythmic groove of the oars moving the boat or the muscle memory timing of the hauls to load the whippy sticks and send it in hopes of positive rewards are my happy places
the john prine pandora station plays as much todd snider as john
buster thinks on levels I aint never gonna gits him and ice can talk deepness that my kiddie pool mind struggles to float in
withs or withouts mind alteration

Sigh... rowing in a boat on calm cool water sounds lovely. Thanks for the visual!

My grandparents had a place on Hood Canal when I was young and I had my own little row boat that I loved to take out.

The water was so clear you could see the seabed with all its starfish and oysters and smooth round rocks. There is something so mesmerizing about how the oar when it rises out of the water creates concentric circles and the water drips off the oar into the center then with a sweep the oar is twisted flat, then down as it slices into the water once again propelling you forward on your journey.

I watch the ripples change their size
But never leave the stream
Of warm impermanence
And so the days float through my eyes
But still the days seem the same

[MultiVerse]

^ Re highangle's head cold and for all the people who had respiratory illnesses earlier this past winter, it's unlikely you had COVID but the good news is if it was caused by one of the other coronaviruses then according to the study you might have some, albeit limited, immunity.

[Core Shot]

early in my Career I learned to never ask a question you didnt know the answer to

Early in my grammar school, I learned to never finish a sentence with a preposition.

#grammarNazi

[KQ]

Early in my grammar school, I learned to never finish a sentence with a preposition.

#grammarNazi

It's not an error to end a sentence with a preposition, but it is a little less formal. In emails, text messages, and notes to friends, it's perfectly fine. But if you're writing a research paper or submitting a business proposal and you want to sound very formal, avoid ending sentences with prepositions.

Ending a Sentence with a Preposition: It’s Ok and It’s Not

#thingschange

[Core Shot]

Cool.
Can we agree about the Oxford comma now?

[XXX-er]

Early in my grammar school, I learned to never finish a sentence with a preposition.

#grammarNazi

.
ohhh can I drink yer bathwater ?

[Deebased]

Hmmm

I'm talking about the hedgehog. Not Ron Johnson. No idea about that guy.

[MultiVerse]

If 80% of Americans wore masks, COVID-19 Infections would plummet, according to a new study.

There’s compelling evidence that Japan, Hong Kong, and other East Asian locales are doing it right and we should really, truly mask up—fast.

If you’re wondering whether to wear or not to wear, consider this. On a given day the first week in May, 21 people died of COVID-19 in Japan. In the United States, 2,129 died. Comparing overall death rates for the two countries offers an even starker point of comparison with total U.S. deaths now at a staggering 76,032 and Japan’s fatalities at 577. Japan’s population is about 38% of the U.S., but even adjusting for population, the Japanese death rate is a mere 2% of America’s.

This comes despite Japan having no lockdown, still-active subways, and many businesses that have remained open—reportedly including karaoke bars, although Japanese citizens and industries are practicing social distancing where they can. Nor have the Japanese broadly embraced contact tracing, a practice by which health authorities identify someone who has been infected and then attempt to identify everyone that person might have interacted with—and potentially infected. So how does Japan do it?

“One reason is that nearly everyone there is wearing a mask”

https://arxiv.org/pdf/2004.13553.pdf

https://www.vanityfair.com/news/2020...new-study-says

[skifishbum]

butts

maybe they can speak
or.....

[Deebased]

Chris Hitchens hit the nail on the head when he partitioned the world into Theists and Nontheists. That is where the discord and divisions lie.

More vapid intellectual puffery from the resident blowfish.

We're all theists choosing to put our faith into different gods.

[XXX-er]

Early in my grammar school, I learned to never finish a sentence with a preposition.

#grammarNazi

if yer so fucking smart go school skifishbum about grandma

at least you can understand what I am writing

[Core Shot]

if yer so fucking smart go school skifishbum about grandma

at least you can understand what I am writing

Wow. Double quote double tap.

Musta hit a nerve. Sorry. It’s all fun. Until the final exam.

But back on point, can we agree that social distancing, hand washing, and Oxford commas are appropriate?