Fear and Loathing, a Rat Flu Odyssey

[Benny Profane]

The meat plants won’t close. Simple economics.
- The demand for meat isn’t going away.
- The bills will begin to stack up for the wage workers that don’t show up, they will be back to work quickly. You don’t get unemployment for being scared...
- The CDC guidelines for operating during COVID are easy to follow, they probably already use the same PPE.
- Management won’t let their bonuses disappear, they will do anything to keep the plants open.


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Just saw the governor of Iowa saying that, if your employer orders you back, no unemployment. This is pretty disgusting. Boycotts are in order.

[glademaster]

Just saw the governor of Iowa saying that, if your employer orders you back, no unemployment. This is pretty disgusting. A general strike is in order.

FIFY

[twat]

Funny, I had a really strange sensation in the toes about three weeks ago. Man, I'd love to get tested. Pretty sure I had it in February.

Does it make a difference if you know you had it or not?

[Benny Profane]

Does it make a difference if you know you had it or not?

I don't know. Just like to know. And the numbers people should, too. Nobody knows shit right now with no testing.

[subtle plague]

Does it make a difference if you know you had it or not?

It matters with drunk sex. Is Corona less important than drunk sex?

[frorider]

Stoked!

[glademaster]

Memes like that should inspire schoolteachers everywhere to cough shamelessly on boomers whenever the opportunity presents itself.

[Benny Profane]

Memes like that should inspire schoolteachers everywhere to cough shamelessly on boomers whenever the opportunity presents itself.

Be careful what you wish for. Who's paying their salaries and benefits?

[Deebased]

Could someone please tell cougs "Goodnight Moon" is not an astrophysics book.

Now that's funny shit!!!

[4matic]

Public golf in California next Monday.

[schuss]

Just saw the governor of Iowa saying that, if your employer orders you back, no unemployment. This is pretty disgusting. Boycotts are in order.

12 months later - "why don't people want to live in our state?"

[Benny Profane]

12 months later - "why don't people want to live in our state?"

Or, next election, "why is my opponent 20 points ahead in polls?"

[Deebased]

Aspen bought 1000 anti-body tests and decided not to use them because they will likely cause more harm than good at this point. If they aren't reliable and there is no guarantee on lasting immunity, what's the point?

It depends on the antibody test and the lab. Efficacy ranges are all over the map both from a timeline from infection and false positive/negative rates.

However, the value is we have a growing body of antibody studies that all point in the same direction.

[Deebased]

The obvious solution is to fucking fire Trump, no?

Absolutely

[wooley12]

yeah those are the batshit crazy Americans in that vid which makes for great press so how about the rest of America ?

I ask cuz up here we don't have the best preconceived notion of the American public

IMO, you can move that notion from preconceived to validated. For every loon on tv there are 500 programmed to cheer him. Another 500 quietly nod and silently agree.

I get both US and Canada on the telly. Seem your news is informative while here it is designed to incite and generate $$$.

[Mofro261]

It depends on the antibody test and the lab. Efficacy ranges are all over the map both from a timeline from infection and false positive/negative rates.

However, the value is when we have a growing body of studies that all point in the same direction.

This paper https://www.medrxiv.org/content/10.1...856v1.full.pdf

compares 11 tests head to head, several with low <90% specificity but 2-3 come in >99% specific with >90% sensitivity. More studies like this will be helpful for validating AB responses.

[54-46]

Public golf in California next Monday.

Fuck yeah!

[old goat]

A friend of ours got sick with symptoms that are a total match for trumpflu, got tested, came back negative, now has blood clots, they won't retest him. 100% coincidence or bogus test?

bogus test

These Americans protesting against the lockdown are both hilarious and terrifying

the guy at 1.50+ at least has a sense of humor

[Tri-Ungulate]

I have missed a bunch of pages, so don't know if this has been covered, but another and very big worry is this virus appears to be causing micro embolisms and causing strokes, renal infarcts and other such clots cause subtle to not so ubtlestble organ damage that may not be reversible. Even mild cases may leave people with organ damage that comes back to haunt them later in life. Trash your kidneys or liver now, and you won't have much reserve later in life when all those years of drinking and partying really come home to roost.

So go ahead and open everything up and let people get infected, what could possibly go wrong?

This is the mechanism by which a lot of younger people are getting into trouble (as well as the expected issues with older patients). I'd kinda alluded to it earlier:

Yeah, it's bringing to mind to me a kind of antiphospholipid syndrome kind of picture. I've been wondering about this a lot lately.

Apologies for the vague musings on my part, that post was kinda oblique.

So I'll explain further: a lot of the microembolic (small clots) phenomena seen in severe cases of SARS CoV 2 reminds me of a condition often seen in the ICU in really sick patients called disseminated intravascular coagulopathy (DIC) but has some key differences that make me think it's not quite that, although there is likely a fair amount of clinical overlap.

In reading the reports, the SARS CoV 2 behaviour brought to my mind a much less common condition called catastrophic antiphospholipid syndrome (CAPS). CAPS is pretty darn rare, I've only been called to consult on it a few times over the years, but the upshot is it manifests as widespread microemboli that can affect a wide variety of organs with severe results - strokes, cardiac arrest, pulmonary failure from clots or bleeding, kidney failure among others, also with skin manifestations from hemorrhage/clotting, usually in the distal extremities like the toes. It's very often fatal. These CAPS symptoms mirror what we're seeing in endstage SARS CoV 2. What causes CAPS is the patient has/develops antibodies to surface antigens on their own cells, primarily proteins involved in plasma phospholipid binding. This is felt to trigger inappropriate clotting in a cascading/snowballing manner, leading to the end result.

It's known that viremias can trigger antiphospholipid antibody formation, well established in earlier studies with several different viruses, including prior coronaviruses. And in fact, a recent paper in New England Journal article from 4/23 describes a case series of SARS CoV 2 patients with coagulopathy (inappropriate clotting) and antiphospholipid antibodies. There's almost certainly other biological factors at work, more than likely having to do with individual patient characteristics such as intrinsic immunity from genetic and environmental exposures, but I think there's a signal here.

As far as treatment for CAPS, that's been a tough nut to crack over the years. A new manufactured monoclonal antibody called eculizumab targets part of the runaway coagulation cascade, and we use it a lot on our service. There's a clinical trial up and running using eculizumab (Solaris) on endstage SARS CoV 2 patients. We'll see how it goes.

[The AD]

From friends with direct experience in Sweden (including a skeptical friend who works at the Karolinska Institute, a biomedical research foundation), Swedes are very much voluntarily physically distancing

Counterpoint to that:
https://slate.com/news-and-politics/...istancing.html

[CarlMega]

yeah those are the batshit crazy Americans in that vid which makes for great press so how about the rest of America ?

I ask cuz up here we don't have the best preconceived notion of the American public

You can feel the nation's bones creak under the weight of these dense MFers. On one had, it's all a bit sad because clearly a few of these people are mentally ill - others, just poorly equipped for a normal life. But the 'both sides' and equal reporting / representation is stifling our progress. In the old days, you said some BS like this and your neighbor would turn to you and go " you know what? you sound like nut"... these days they get media time and forums that appear semi-legitimate and become part of the public debate. Madness. It degrades the entire conversation. One girl in the video did have massive cans tho.

[uglymoney]

12 months later - "why don't people want to live in our state?"

Exactly. Disgusting.



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[old goat]

A friend of ours got sick with symptoms that are a total match for trumpflu, got tested, came back negative, now has blood clots, they won't retest him. 100% coincidence or bogus test?

This is the mechanism by which a lot of younger people are getting into trouble (as well as the expected issues with older patients). I'd kinda alluded to it earlier:



Apologies for the vague musings on my part, that post was kinda oblique.

So I'll explain further: a lot of the microembolic (small clots) phenomena seen in severe cases of SARS CoV 2 reminds me of a condition often seen in the ICU in really sick patients called disseminated intravascular coagulopathy (DIC) but has some key differences that make me think it's not quite that, although there is likely a fair amount of clinical overlap.

In reading the reports, the SARS CoV 2 behaviour brought to my mind a much less common condition called catastrophic antiphospholipid syndrome (CAPS). CAPS is pretty darn rare, I've only been called to consult on it a few times over the years, but the upshot is it manifests as widespread microemboli that can affect a wide variety of organs with severe results - strokes, cardiac arrest, pulmonary failure from clots or bleeding, kidney failure among others, also with skin manifestations from hemorrhage/clotting, usually in the distal extremities like the toes. It's very often fatal. These CAPS symptoms mirror what we're seeing in endstage SARS CoV 2. What causes CAPS is the patient has/develops antibodies to surface antigens on their own cells, primarily proteins involved in plasma phospholipid binding. This is felt to trigger inappropriate clotting in a cascading/snowballing manner, leading to the end result.

It's known that viremias can trigger antiphospholipid antibody formation, well established in earlier studies with several different viruses, including prior coronaviruses. And in fact, a recent paper in New England Journal article from 4/23 describes a case series of SARS CoV 2 patients with coagulopathy (inappropriate clotting) and antiphospholipid antibodies. There's almost certainly other biological factors at work, more than likely having to do with individual patient characteristics such as intrinsic immunity from genetic and environmental exposures, but I think there's a signal here.

As far as treatment for CAPS, that's been a tough nut to crack over the years. A new manufactured monoclonal antibody called eculizumab targets part of the runaway coagulation cascade, and we use it a lot on our service. There's a clinical trial up and running using eculizumab (Solaris) on endstage SARS CoV 2 patients. We'll see how it goes.

https://www.hematology.org/covid-19/...d-coagulopathy

[Mofro261]

This is the mechanism by which a lot of younger people are getting into trouble (as well as the expected issues with older patients). I'd kinda alluded to it earlier:



Apologies for the vague musings on my part, that post was kinda oblique.

So I'll explain further: a lot of the microembolic (small clots) phenomena seen in severe cases of SARS CoV 2 reminds me of a condition often seen in the ICU in really sick patients called disseminated intravascular coagulopathy (DIC) but has some key differences that make me think it's not quite that, although there is likely a fair amount of clinical overlap.

In reading the reports, the SARS CoV 2 behaviour brought to my mind a much less common condition called catastrophic antiphospholipid syndrome (CAPS). CAPS is pretty darn rare, I've only been called to consult on it a few times over the years, but the upshot is it manifests as widespread microemboli that can affect a wide variety of organs with severe results - strokes, cardiac arrest, pulmonary failure from clots or bleeding, kidney failure among others, also with skin manifestations from hemorrhage/clotting, usually in the distal extremities like the toes. It's very often fatal. These CAPS symptoms mirror what we're seeing in endstage SARS CoV 2. What causes CAPS is the patient has/develops antibodies to surface antigens on their own cells, primarily proteins involved in plasma phospholipid binding. This is felt to trigger inappropriate clotting in a cascading/snowballing manner, leading to the end result.

It's known that viremias can trigger antiphospholipid antibody formation, well established in earlier studies with several different viruses, including prior coronaviruses. And in fact, a recent paper in New England Journal article from 4/23 describes a case series of SARS CoV 2 patients with coagulopathy (inappropriate clotting) and antiphospholipid antibodies. There's almost certainly other biological factors at work, more than likely having to do with individual patient characteristics such as intrinsic immunity from genetic and environmental exposures, but I think there's a signal here.

As far as treatment for CAPS, that's been a tough nut to crack over the years. A new manufactured monoclonal antibody called eculizumab targets part of the runaway coagulation cascade, and we use it a lot on our service. There's a clinical trial up and running using eculizumab (Solaris) on endstage SARS CoV 2 patients. We'll see how it goes.

The Cell paper linked below proposes direct viral infection of blood vessels and capillary beds via ACE2 receptors on vascular smooth muscle endothelial cells and in kidney tubules.

https://www.sciencedirect.com/scienc...92867420303998

[twat]

It matters with drunk sex. Is Corona less important than drunk sex?

i used to touch my anus after a blackout drunk night. no pain, no sourness, no wear and tear : ) happy days all good in the hood