I'd bump up to Savage model 10/110 instead of the Axis. Much more aftermarket support and a nicer action out of the box. I have one in .300 win mag.
On a different note... one of my employees brought out a .500 S&W X-Frame on our last company range day. He had some "Light" 385gr loads and some heavy 700gr loads. Needless to say the 700gr had some serious recoil:
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