
Originally Posted by
Viva
d00d, I've been wondering a lot about this myself. This is especially important in the "Wear a mask lest you infect others" bitch slapping contest occurring nation-wide. Regrettably, I find that there is a paucity of published data to make any reasonable conclusions with respect to the asymptomatic crowd (understandable as this group is more difficult to identify) vs. "Full Blown Covid" group (the “Symptomats”).
Earlier today I read two reports (one non-peer reviewed) that shared clinical observations (i.e., they weren't hypothesis-driven studies). And while these observations seemed interesting (they report that the Symptomats have either 33 or 100-fold the viral capacity that the Asymptomats do, depending on the report, with the peak viral load occurring at either 4.1 or 2.7 days prior to the onset of symptoms, I had no idea if these are valid observations. No controls, don’t know if their methods were valid, didn’t recognize their statistical tests. Can't derive anything useful from this. I’m guessing that any report on Asymptomats will prove equally painful to figure out.
Maybe a bit simple-minded (I never did a clinical study), but in order to gain anything meaningful, you’d perhaps have to design a study in which a reasonably diverse cohort are exposed to Bat-Death Virus concurrently, in an infection-inducing dose, and then subsequently tested daily for virus and / or viron capacity, while observing for COVID-19 symptoms. This may provide a reasonable way to distinguish between the Symptomats and Asymptomats as far as their ability to infect. I doubt that such a study would ever be approved in the US for obvious reasons.
Simple-minded proposals aside, from the beginning of this 2020 Bat-Death Virus odyssey, and especially due to limitations in understanding certain aspects of the epidemic, my thinking has generally followed the tenet of Oscar Meyer's Razor; the simplest explanation is often best (Cause if I were a Oscar Mayer razor, Everyone would be in love, Oh everyone would be in love, Everyone would be in love with me). Under this supposition, folks not presenting symptoms or just mild symptoms have immune systems that are kicking virus ass, leaving little opportunity for repeated replication cycles. Their viral capacity will thus be significantly lower than any Symptomat. Of course this group can still theoretically infect others, with such likelihood being dependent on other (myriad) factors. But knowing what their capacity to infect would certainly aid in resolving the on-going arguments on masks as well as allow for informed government policy at all levels.
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