I have seen the light. I believe in mRNA vaccines and therapeutics.
Anyway, the sales pitch is hella compelling.
https://www.modernatx.com/sites/defa...50317_v8_4.pdf
https://horizon-magazine.eu/article/...-vaccines.html
It's mRNA synthesis (or playing god from the ground up) + some biochemical engineering. No coronaviruses. No cell cultures to make viral vectors. Or even protein subunits. No muss, no fuss.
1. A computer has the genetic code for the mRNA that you want to make, and mixes some chemicals. For the coronavirus pandemic, the code to make the SARS-CoV2 spike protein. Clean up and out comes the purified mRNA.
2. Stick the mRNA into lipid nanoparticles. Fatty spheres, about the diameter of one wavelength of visible light. The lipid nanoparticles transport the mRNA into cells. Where it works with the cells ribosomes to synthesize proteins. Unlike DNA, it doesn't have to get into cells' nuclei.
Not as effective as a chimpanzee adenovirus at getting into cells, but safer.
Doesn't cost billions for industrial scale biotech breweries.
If the virus mutates, punch in the code for the mutation
Videos that go into detail.
With a little biotech trash talking about who's going to save the world.
Recombinant is old school. It's mRNA vs. self amplifying mRNA.
Sponsor Introduction: Clem Lewin, Ph.D., associate vice president of R&D strategy for vaccines, Sanofi
Tal Zaks, chief medical officer, Moderna
Matthew Herper, senior writer, medicine, and editorial director of events, STATCombating Covid-19: Part 3 - Vaccines — can they come soon enough?
https://www.youtube.com/watch?time_c...ture=emb_title
https://www.youtube.com/watch?v=YcWZ...ature=youtu.be
Reasonable about vaccines having to be proven to work.
Science fiction about hospitals having the equipment to manufacture mRNA vaccines, "We're just emailing an electronic sequence now, of the key antigen."
"But there's no mistaking that a self amplifying RNA has both an antibody and a T cell response. And this might be important for a coronavirus."
Vaccines are the magic bullet. But if there's a flare up in the fall, there'll be tremendous pressure for antibody therapeutics. Then maybe manufacturing of monoclonal antibodies vs. mRNA therapeutics.