Weather should be just fine in early Oct. Cool but fine. Tioga Road is usually open into early November.
Where are you staying, and where are you coming in from? Yosemite can take a while to navigate.
As for the general to-do, the waterfalls in the valley will be mostly dried up except for Vernal/Nevada by October unless we get some early rains. If your folks are in good shape, the trail is a paved superhighway to Vernal but it's all uphill and doesn't let up. Beyond the Vernal fall bridge the surface gets rougher. You can actually use google street view to hike the mist trail/John Muir trail and gauge the difficulty. (yeah, it gets a lot of traffic). Don't skip the tunnel view on the south side of the valley even though it's packed with tourists.
Renting bikes and cruising the valley floor via beach cruiser is still on my bucket list. You can rent them at the village. Lots of great bike paths, super chill way to spend the day and enjoy the granite all around you. Mind the deer.
Try not to drive on the valley floor, traffic sucks, parking is even worse, and deer are everywhere. The valley shuttle is free and good.
Get a cocktail at the Ahwahnee hotel and sit on the patio for an hour in the afternoon.
Glacier Point is still a favorite lookout of mine, and the meadows on the way are nice too. If someone is stir crazy from the ride, they can head down 4 mile trail into the valley and the car can meet them at the bottom.
Tuolumne Meadows in the high country is wonderful, but keep in mind your at 8,600' + so it will be cold and potentially snowy. If you want to drive the pass, head down to Lee Vining and the famous MoMart for lunch. May as well check out Mono Lake while you're there, but Yosemite is more spectacular.
Mariposa Grove is closed for major repairs until spring 2017. Don't bother with the South end of the park right now. If you want to see the giant sequoias, you'll need to go to Tuolumne or Merced Groves. Bring water, there isn't any on either trail.
If you head out of the park and down highway 120 for a little way, you'll come upon the Rim of the World Vista, and you'll see part of the damage from the Rim fire of 2013 (~250,000 acres). Horrifying and beautiful in its own way.
I've concluded that DJSapp was never DJSapp, and Not DJSapp is also not DJSapp, so that means he's telling the truth now and he was lying before.
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