I believe that the phrase "S'up Holmes" originated in the Gerry Cooney/Larry Holmes title fight in 1982. Cooney's trainer at the time, Victor Valle Sr., in an attempt to infuriate Holmes during the fight, told Gerry to ask the question "What's going on, Larry?"
Cooney, following the advice of his trainer, would ask Holmes the question at the beginning and end of each round. However, having taken a severe beating for most of the fight, Cooney continued to shortened the phrase as the rounds progressed so as not to piss off Holmes. So by the end of the fight, what had originally been a phrase of "What going on, Larry?" was shortened to "S'up Holmes."
And there you have it.
Charlie, here comes the deuce. And when you speak of me, speak well.
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