
Originally Posted by
splat
Seems legit. But, shit, let's see what the National Institute of Health says.
Abstract
Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations. It is currently used for this purpose in diclofenac sodium topical solution (approved in the United States to treat signs and symptoms of osteoarthritis) and idoxuridine topical solution (approved in Europe for the treatment of herpes zoster). This article reviews the mechanism of action of DMSO as a pharmaceutical penetration enhancer, the characteristics of the molecule that facilitate transdermal drug delivery, and studies of efficacy and safety. The clinical use of pharmaceutical-grade DMSO as a penetration enhancer is supported by the robust data that have accumulated over the past 3 decades demonstrating the favorable safety and tolerability profile. Dimethyl sulfoxide is a safe and effective mechanism for facilitating the transdermal delivery of both hydrophilic and lipophilic medications to provide localized drug delivery.
https://www.ncbi.nlm.nih.gov/pubmed/22030943
Prolly not as qualified as my stalker, DTM, but they have an opinion, too.
I've done a lot of work with DMSO as a solvent, putting some pretty toxic compounds into it looking at druggable targets in cell based enzyme screens. We always ran a DMSO % concentration control alone vs Saline or buffer alone, because even 0.1% DMSO had a physiological effect in our assays. It's also my go-to as a cryo-protectant when I'm freezing down cell lines, usually 8-10% DMSO is added to prevent cell damage for storage in liquid nitrogen.
Here's a recent review for human applications-
Adverse reactions of dimethyl sulfoxide in humans: a systematic review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707402/
Background: Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a pharmacological agent in humans since the 1960s. Today, DMSO is used mostly for cryopreservation of stem cells, treatment of interstitial cystitis, and as a penetrating vehicle for various drugs. Many adverse reactions have been described in relation to the use of DMSO, but to our knowledge, no overview of the existing literature has been made. Our aim was to conduct a systematic review describing the adverse reactions observed in humans in relation to the use of DMSO.
Methods: This systematic review was reported according to the PRISMA-harms (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines. The primary outcome was any adverse reactions occurring in humans in relation to the use of DMSO. We included all original studies that reported adverse events due to the administration of DMSO, and that had a population of five or more.
Results: We included a total of 109 studies. Gastrointestinal and skin reactions were the commonest reported adverse reactions to DMSO. Most reactions were transient without need for intervention. A relationship between the dose of DMSO given and the occurrence of adverse reactions was seen.
Conclusions: DMSO may cause a variety of adverse reactions that are mostly transient and mild. The dose of DMSO plays an important role in the occurrence of adverse reactions. DMSO seems to be safe to use in small doses.
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Splat's cream works great on shoulders, less so on knees. I sort of chalked that up to needing deeper penetration into the knee joint, as I could definitely feel it working for the contact sensitivity I had related to the incision. Just about due for another jar soon.
Move upside and let the man go through...
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