Cool Science thread

[LegoSkier]

https://www.geekwire.com/2018/microsoft-partnership/

https://blogs.microsoft.com/blog/201...treat-disease/

Some next level shit announced by my company in partnership with Microsoft today. This has always been our end goal but this (and a lot of hard science, AI power, and luck) will hopefully make it a reality. Basically, your immune system has a record of every disease you have and have ever had. Right now, the record is there and Adaptive is good at reading the record, but we can’t really understand the meaning. This project is basically using a shit ton of (Microsoft provided) AI/Machine Learning power, running on their cloud infrastructure of course, to decode that record and understand it. If we can do that, pretty much everything we know about diagnosing, monitoring, and even treating, well pretty much everything, drastically changes.

[The Suit]

https://www.geekwire.com/2018/microsoft-partnership/

https://blogs.microsoft.com/blog/201...treat-disease/

Some next level shit announced by my company in partnership with Microsoft today. This has always been our end goal but this (and a lot of hard science, AI power, and luck) will hopefully make it a reality. Basically, your immune system has a record of every disease you have and have ever had. Right now, the record is there and Adaptive is good at reading the record, but we can’t really understand the meaning. This project is basically using a shit ton of (Microsoft provided) AI/Machine Learning power, running on their cloud infrastructure of course, to decode that record and understand it. If we can do that, pretty much everything we know about diagnosing, monitoring, and even treating, well pretty much everything, drastically changes.

That's cool, but why no blockchain?

[zartagen]

That's cool, but why no blockchain?

The immune system is, like, the blockchain of the body, man.

[abraham]

The immune system is, like, the blockchain of the body, man.

Sick people have more blocks calculated -> sick people are worth more -> their bills get covered

Or something.


Still that's a cool project!

[huckbucket]

Call me super skeptical. Given the diversity of immune response as represented by T and B cell variability even to the same antigen or peptide, the training set for this is going to have to be beyond enormous. Hell, across similar tumor types there's a dramatic lack of neo-epitope sharing.

[PB]

What he said.

Whatever it was......

[LegoSkier]

Call me super skeptical. Given the diversity of immune response a represented by T and B cell variability even to the same antigen or peptide, the training set for this is going to have to be beyond enormous. Hell, across similar tumor types there's a dramatic lack of neo-epitope sharing.

Yeah. This is far from a sure thing. We have a process that works at small scale (even across a sample population) but we don't truly know if it will work across the greater population or across many antigens. Hence the need for Microsoft to scale this. For sure this is going to be processing data at a truly bizarre level. If successful in the future there will be many acres of server farms dedicated to this.

[huckbucket]

Yeah. This is far from a sure thing. We have a process that works at small scale (even across a sample population) but we don't truly know if it will work across the greater population or across many antigens. Hence the need for Microsoft to scale this. For sure this is going to be processing data at a truly bizarre level. If successful in the future there will be many acres of server farms dedicated to this.

Go get em! Is your process published? Would love to see a little more around the approach.

[LegoSkier]

Go get em! Is your process published? Would love to see a little more around the approach.

Not all of it. This is the piece that is: http://journals.plos.org/plosone/art...l.pone.0141561

[Dantheman]

Damn, Lego, that is some truly next-level stuff.

Did anyone else see the articles that came out recently about the "gravitostat" discovery? I normally find non-human obesity studies pretty boring, but this one is an exception. Researchers implanted rats and mice with weights equivalent to 15% of their body weight. Within a couple weeks they had lost an amount of body fat equivalent to the weight of the implants and returned to their pre-implant weight. Weight loss was solely the result of reduced food intake; the animals did not increase their physical activity. They got the same results using leptin-knockout mice, but not with mice deficient in osteocytes. Thus, our bones appear to have an osteocyte-dependent internal scale that regulates body fat storage and appetite independent of leptin. Pretty cool, and further evidence that the best way to not get fat is to sit on your ass as little as possible.

https://www.medicalnewstoday.com/articles/320498.php

[Dantheman]

"In 87 of 90 mice, the cancers were eradicated."

"I don't think there's a limit to the type of tumor we could potentially treat, as long as it has been infiltrated by the immune system," Dr. Levy stated.

https://www.genengnews.com/gen-news-...d-far/81255449

Paging huckbucket, LegoSkier.... As presented, this sounds like quite a breakthrough.

[The Suit]

"In 87 of 90 mice, the cancers were eradicated."

"I don't think there's a limit to the type of tumor we could potentially treat, as long as it has been infiltrated by the immune system," Dr. Levy stated.

https://www.genengnews.com/gen-news-...d-far/81255449

Paging huckbucket, LegoSkier.... As presented, this sounds like quite a breakthrough.

Sounds too good to be true. I hope it's not.

[SKIP IN7RO]

It's all wood and cool.
https://www.scientificamerican.com/a...-s-super-wood/
"Although Hu and his team have sought to enhance wood’s strength, other researchers have pursued more unusual goals—such as making it transparent."

[huckbucket]

"In 87 of 90 mice, the cancers were eradicated."

"I don't think there's a limit to the type of tumor we could potentially treat, as long as it has been infiltrated by the immune system," Dr. Levy stated.

https://www.genengnews.com/gen-news-...d-far/81255449

Paging huckbucket, LegoSkier.... As presented, this sounds like quite a breakthrough.

That data was published in another form more than 15 years ago and then tested in in humans not long after. Concept holds merit but didn't translate. The latest version you linked used a slightly different approach, but may still be stymied by the disconnect in biology between humans and mice. Case in point, the tumors that are being challenged in that study are exceptionally immunogenic and look unlike most human tumors. It's likely one reason why the response was so strong. Still interesting though.

[Norseman]

Existence of Ice-7 confirmed in a surprise discovery using x-rays to examine deeply-formed diamonds:

http://www.latimes.com/science/scien...308-story.html


More deep geo:

https://www.nature.com/articles/nature25972

[Tri-Ungulate]

Godspeed. We will all eventually be constituent mass and energy.

[MakersTeleMark]

Guy pushed tech more then Gates and Jobs combined.

In many ways.

I don't think Godspeed is a proper sendoff.

May you be sucked into a massive vortex of death and life would be more validating, I would guess.

[Dantheman]

Hawking's final paper suggests a method to experimentally prove the existence of the multiverse
https://www.telegraph.co.uk/science/...al-multiverse/

Technical version. I'm pretty sure it's in english, but I have doubts.
https://www.nextbigfuture.com/2018/0...ce-in-cmb.html

Apparently, it also predicts that the ultimate fate of our universe is heat death, which is a tad depressing.

[JimmyCarter]

Technical version. I'm pretty sure it's in english, but I have doubts.
https://www.nextbigfuture.com/2018/0...ce-in-cmb.html

I used to love watching some of those Susskind/Stanford "dumbed down" physics lectures on youtube, even after realizing I just had to take 80% of what he was saying as a given because it was that far over my head.

[abraham]

Apparently, it also predicts that the ultimate fate of our universe is heat death, which is a tad depressing.

I have an ex who found the heat death of the universe comforting. I disagreed

[iceman]

I'm lukewarm on the idea myself.

[JimmyCarter]

I'm lukewarm on the idea myself.

Give it time and that will change.

[Mazderati]

This is the cool science thread.

[iceman]

This is the cool science thread.

Hey chill the fuck out man.

[Mazderati]

Hey chill the fuck out man.

Did that come off hotheaded? My bad.