WEED, The Official Thread

[OregonDead]

In Oregon people just gift it now too but they ask for nothing in return. Or the signs out on the street says it's like $50/Oz or $1/g.

In DC, yes that's what I hear. They give you a t-shirt or something for bucks and they "gift" you the weed.

[prsboogie]

Cannabis users needed up to twice the sedation for medical procedures, small study says

CNN)People who regularly use cannabis may need two times the level of sedation required by nonusers when undergoing medical procedures, a small-scale study finds. Fentanyl, midazolam and propofol, three sedation drugs commonly used during endoscopic procedures, were compared in the research.

With "continued increase in legalization and use of cannabis, the field of anesthesia and sedation needs further studies with greater depth," wrote the authors of the study, published Monday in The Journal of the American Osteopathic Association.

Wider use follows legalization

Marijuana has gained popularity around the globe in recent years due, in part, to changing laws. Between 2007 and 2015, use of marijuana increased 43% in the United States, where an estimated 13.5% of adults use cannabis, according to a United Nations report. Meanwhile, cannabis use around the world was estimated to include 183 million people, or nearly 4% of the adult population, in 2015.

How does increasing cannabis use affect medical care? Researchers at Community Hospital in Grand Junction, Colorado, explored one small area of medical care: sedation. They examined the medical records of 250 patients who received endoscopic procedures between January 1, 2016, and December 31, 2017 -- years after the state legalized recreational marijuana in 2012.

Comparing cannabis users to nonusers, they found that patients who reported smoking or using edibles on a daily or weekly basis required 14% more fentanyl, 20% more midazolam and 220% more propofol to achieve optimum sedation for routine procedures, including colonoscopies. For example, it took 13.83 milligrams of propofol, on average, for 225 nonusers to float into unconsciousness, compared with 44.81 milligrams needed, on average, by 25 cannabis users.

The study authors note that some sedatives have side effects and the higher the dose, the greater likelihood for problems. Asking questions about cannabis use during intake "can be an important tool for planning patient care and assessing both medication needs and possible risks during endoscopic procedures," they wrote.

Too few study participants

Dr. Roderic Eckenhoff, a professor of anesthesia at the University of Pennsylvania, said the study is interesting but lacked rigor. "I would consider this a pilot study that maybe somebody should pick up on and do a more complete trial," said Eckenhoff, who was not involved in the research.

One factor that bothered him was that the study was retrospective: The researchers simply examined medical records and compared whatever amount of sedation was used for each patient instead of controlling exact amounts of sedation and comparing the effects.

What is considered "enough" depends a lot on the individual providers and surgeons involved, Eckenhoff said. This "uncertainty" combined with a small number -- just 25 -- of cannabis-using patients makes the results "really tenuous at best," he said.

Similar results have not been seen in previous research, he said: "Even if you give someone propofol for a long time, they get a little tolerant to it, but not by 200%." Although upward of 200% "resistance" may be "possible, I'd be surprised if that held up in a bigger study," he said.

Finally, he noted that patients are not always reliable and don't necessarily tell their doctors about "everything else that they take," and this may have influenced the results: "Some people who use marijuana also take other drugs recreationally."

I worked in PACU for 5 years and I will say there was a very consistent correlation with increased anesthesia needs with people who partook in recreational ingestion. Obviously I have not done specific research but trends are recognizable.

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[JimmyCarter]

some good questions, hope my explanation above helps,
your mileage will vary with regard to effect and duration.

No heat = not activated = dont drink the vape oil

[Dantheman]

What's the definitive guide for preparing DIY tincture?

[FlimFlam]

If you have the time to get across the bridge in to SF you should check out Barbary Coast. They provide plenty of complimentary supplies(dab rigs, vaporizers, rolling papers etc) in their lounge to enjoy your purchases if you choose to chill, work, have a meeting or watch a game in their lounge. All individuals over 21 can purchase legally in CA regardless of state or nation on your documentation.

This place is a solid recommendation.
Nice spot

[jgb@etree]

What's the definitive guide for preparing DIY tincture?

1oz of GOOD bud decarb'd* per cup of everclear, 151, or other high proof alcohol (see previous post for my new favorite)

Brew it for 4-8 hrs @ 130F - the longer the brew, the stronger your tincture will be. I always do 8hrs. Use your brain on this since the booze is highly flammable. A magic butter machine makes it idiot simple.

Strain, bottle & consume.

*too many people skip this absolutely critical step. It's the difference between 'this is pretty cool' and 'holy shit, this stuff is amazing'

[ticketchecker]

I've got a full mason jar of some clean W VA shine, may have to try a batch

[mooseknuckles]

Try using Everclear 190 instead of the 151

[jgb@etree]

Try using Everclear 190 instead of the 151

Unless I am mistaken, all everclear is 190. 151 is a Baccardi rum. The Wray & Nephew over proof that I'm recommending is only around 130.

If my understanding is correct, the 'advantage' of the over proof rums vs grain alcohols are due to the fact they are distilled from sugar cane (wray's) or molasses (baccardi 151) as oppose to corn (everclear).

[mooseknuckles]

^ gotcha. I thought you were using Everclear 151. 190 proof alcohol is illegal/not for sale in many states. Everclear 151 is sold in states that do not sell Everclear 190. Identical looking bottles, only difference is the proof number.

[Fritz]

cane alcohol is a good base and used in the decarb process by a few different processors. wouldn’t surprise me if the Fairwinds folks use cane alcohol to make some of their erl.

So did you heat your mixture then or just mix in the erl?

[Dantheman]

Recently had a conversation w a friend who has been making an amazing tincture for a long time. Despite following his basic recipe for years, I could never get my tincture to be quite as good as his. Turns out that I was using an inferior ingredient: everclear. He uses a sugar based moonshine that a friend of his makes. He's a brewer and understands the 'chemistry' better than I do, but said someshit about the thc absorbing better in the sugar based 'shine.

This reeks of BS. Ethanol is ethanol regardless of the source it's derived from, and sucrose has no solvent properties.

Brew it for 4-8 hrs @ 130F - the longer the brew, the stronger your tincture will be. I always do 8hrs. Use your brain on this since the booze is highly flammable.

Last night's googling suggests the only advantage of heating it is expediency. Sure, waiting two weeks while it sits in a cabinet kinda sucks, but sounds preferable to babysitting it on the stove for 8 hours.

[Fritz]

Yum

[jgb@etree]

This reeks of BS. Ethanol is ethanol regardless of the source it's derived from, and sucrose has no solvent properties.

someshit about the thc absorbing better in the sugar based 'shine.

Again, my understanding is not that the sugar based alcohol dissolves the thc better, but that it binds to the sugar based booze better than the grain based & would assume that is why I am getting much better results with 130 proof sugar based booze than 190 proof grain. Kinda like making weed butter with & without lecithan. You don't need to add lecithin to the mix, but if you do the butter becomes much more potent because the lecithin helps absorb/bond the thc to the butter.

Last night's googling suggests the only advantage of heating it is expediency. Sure, waiting two weeks while it sits in a cabinet kinda sucks, but sounds preferable to babysitting it on the stove for 8 hours.

I used to do the month soak before I discovered the magic butter machine a couple of years ago, and the end result is nowhere near as good as the cooked method, but have at it. The magic butter machine is the perfect solution to not having to babysit anything.

https://magicalbutter.com/

But then again, you're now an expert on the topic. So definitely go out on internet forums, ask how to make tincture and then argue with the advice of people who have been doing this shit for years.

[Dantheman]

Again, my understanding is not that the sugar based alcohol dissolves the thc better, but that it binds to the sugar based booze better than the grain based & would assume that is why I am getting much better results with 130 proof sugar based booze than 190 proof grain.

I have quite a bit of formal education in chemistry. If you have a non-broscience source that supports this hypothesis, I'm all ears.

I used to do the month soak before I discovered the magic butter machine a couple of years ago, and the end result is nowhere near as good as the cooked method, but have at it. The magic butter machine is the perfect solution to not having to babysit anything.

https://magicalbutter.com/

But then again, you're now an expert on the topic. So definitely go out on internet forums, ask how to make tincture and then argue with the advice of people who have been doing this shit for years.

Hey, I'm just parroting other sources who also have years of experience on this topic and generally seem to disagree.

ETA: Freezer method actually sounds like the best option.

[Norseman]

Do you even Bro-Science, bro?

[Dantheman]

What does "all organic" mean though? From sugar or grain it's all "organic". Maybe they're saying it's not done is iso alcohol

Assuming that it's an OFPA-compliant label, it means that the ethanol was fermented from organically-produced source crops. Also assuming that it was subsequently refined to a laboratory-grade product, there's no meaningful difference compared to non-organic ethanol.

[Game Over]

Years ago when I was first getting into making tinctures I actually got a batch right for the first time. Took a shot like I usually did and the test dose made me sleep for 2 days!

[Skidog]

Assuming that it's an OFPA-compliant label, it means that the ethanol was fermented from organically-produced source crops. Also assuming that it was subsequently refined to a laboratory-grade product, there's no meaningful difference compared to non-organic ethanol.

This is what I figured

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[TBS]

According to the New York Times I am a "high per-capita consumption consumer"

Eager to shake the image of being high-end drug dealers, cannabis companies have become hypersensitive to anything that sounds unprofessional — hence the insistence on calling the substance cannabis instead of pot, weed or marijuana. Buds are “flower.” Hash is “extract.” Stoners are “high per-capita consumption consumers.”

https://www.nytimes.com/2019/04/25/b...marijuana.html

[Bobby Stainless]

Harborside has some good flower. Got some Jungle Boys Sundae Driver.

Really impressed with the baby food jars and humidification packets in them.

Everything in CO turns to dust.

[pyromaniacman129]

Oh FFS....


https://www.usatoday.com/story/opini...mn/3587406002/

[jackstraw]

Oh FFS....


https://www.usatoday.com/story/opini...mn/3587406002/

http://momsstrong.org/

[pyromaniacman129]

I feel for the families who have lost loved ones to mental health issues but I don't think the MJ is the real issue in those cases. It may amplify some things but if you're having trouble with mental health the last thing you should be doing is overindulging in any type of drug use.

[KQ]

I feel for the families who have lost loved ones to mental health issues but I don't think the MJ is the real issue in those cases. It may amplify some things but if you're having trouble with mental health the last thing you should be doing is overindulging in any type of drug use.

It could have just as easily been something else, food (over indulgence/anorexia/bulimia ), alcohol, prescriptions, risky/self destructive behavior or perhaps just the availability of a gun close at hand. It is sad and just as alcohol isn't for everyone either is cannabis (both of which have been illegal and legal without much change in use).

Absent [insert "drug" of choice] it probably would have been something else. Again, a sad situation for all involved.