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https://www.menshealth.com/health/a2...ing-rapamycin/
There are hundreds, perhaps thousands, of men quietly experimenting with rapamycin across the country. And if these guys are right, they could be like the lucky rodents in the research, walking around with improved brain health, heart health, and vitality while the rest of us surrender to mortality. Or they could be killing themselves slowly. It’s too soon to tell.
Men's Health? Come on, man. The PubMed article's first words are "From the dawn of civilization..." How's Men's Health gonna compete with that?
I don't portend MH is the goto for definitive research and information, but some of the anecdotal tidbits found in the article did pique my interest and a few more years of study could have me looking for Rapamycin offshore - I'm Old (in years).Quote:
Originally Posted by jono
Dr. Green in Brooklyn is only 90min away. Sadly, he's not accepting Medicare
What’s the latest on metformin? I thought that was the latest anti aging trend my drug?
Tongue got stuck in cheek. More of a reference to the opening line, really.Quote:
Originally Posted by Gepeto
Harvest Moon, Supermoon and a partial lunar eclipse going on right now. Top left corner is obscured.
According to the researchers’ calculations, the metformin had made these monkeys’ brains six years younger on average, which could potentially translate to 18 years in humansQuote:
Originally Posted by mcski
...the study’s findings are still based on a small sample size, and cynomolgus monkeys may have important biological differences that could affect the activity of metformin. These caveats mean that we can’t be certain about metformin’s fountain-of-youth effect in humans, at least not yet. But the results certainly do provide more incentive to keep digging.
https://gizmodo.com/a-common-diabete...ins-2000499935
Space is big. That’s why we call it “space”
For decades, astronomers and planetary scientists have wondered exactly what it was that hit Earth 66 million years ago and caused the extinction of 75%! of all species of life, including the non-avian dinosaurs. Was it a comet or an asteroid?
We know it was big, 10 kilometers across or so, and hit in the Gulf of Mexico just off the Yucatan coast, a site called Chicxulub (CHICK-shoo-lube). The impact was so large — it dwarfed the combined explosive yield of every nuke on the planet, equaling about a hundred million megatons* — it ended the Cretaceous geological period and introduced the new Paleogene period.
...
The dinosaur killer asteroid came from deep space, in the outer solar system. Ruthenium isotopes reveal the secrets of the Chicxulub impactor. By carefully measuring [ruthenium isotope ratios], scientists can identify where the material came from.
In this case, the ratio closely matches not just that of asteroids, but carbonaceous chondrite asteroids. Chondrites are asteroids that don’t show any modification by thermal processes (like melting), and carbonaceous means they have more carbon in them than average. Because they were never heated, these types of asteroids are thought to have formed in the outer solar system when the Sun and planets were born, and have remained largely unmodified by large impacts ever since.
...
Seeing as how there are still a lot of asteroids out there, I kinda feel like the more we know the better, especially if we find one headed our way and need to send up a space probe to knock it out of the way à la DART. The asteroid’s composition and tensile strength will make a huge difference in how well that sort of thing would succeed.
https://badastronomy.beehiiv.com/p/d...r-solar-system
Failed in the ITP: https://www.nia.nih.gov/research/dab...-interventionsQuote:
Originally Posted by mcski
Reanalysis of the study that initially suggested longevity benefits indicates that it was a false signal in the data:
https://peterattiamd.com/a-recent-me...y-indications/
https://pubmed.ncbi.nlm.nih.gov/36287641/
A couple of clinical trials, MILES (Metformin In Longevity Study) and TAME (Targeting Aging with Metformin), are currently in process. Preliminary data from these trials indicates a possible healthspan benefit even if there is no lifespan benefit (https://www.frontiersin.org/journals...21.718942/full), but the likely mechanisms (anti-hyperglycemia, improved insulin sensitivity, reduction of oxidative stress) suggest that you're much better off just exercising.
There's a huge study in progess to assess whether Rapa extends the lifespan of dogs (https://dogagingproject.org/), but sadly it looks like they are going to lose their NIA grant funding and unless they can raise $50 million privately we likely won't ever see the results (https://www.science.org/content/arti...y-lose-funding).Quote:
Originally Posted by whipski
The math of voting.
https://youtu.be/qf7ws2DF-zk?si=ldoP_XhWM85jD2uU
Possible to glitch in the least likely edge cases /= impossible. Should have addressed the probability of weirdness. It's low.
Nobel prize in Chenistry awarded to David Baker at UW and 2 others for their work related to protein structure prediction.
About as close as I'll ever get, colloraborated ~20 yrs ago with his lab to get an article in Science that was awarded the Newland Clevand Prize (arti le of the year) bitd. Turns that the paper I'm an author on is the reason for the Nobel.
Let me be the first to say "congratulations for that, it's one helluva lot closer to a Nobel than this schmuck will ever get!"Quote:
Originally Posted by Mofro261
Very cool!
^^ just saw that, Mofro. Very cool.
Came here to post this: https://lumenategrowth.com/
I only heard of this today and haven't tried it yet (but plan to, later on), but the concept is pretty cool and apparently it works, from the little I've had a chance to read so far.
++++!!!!Quote:
Originally Posted by Mofro261
Super cool mofro!
Perhaps more cool engineering than pure science, still amazing: SpaceX caught their 230ft tall Starship heavy booster on their 1st attempt!
Video of the catch: https://x.com/SpaceX/status/1845442658397049011
Attachment 502014
I parked in a Nobel laureate spot on the Berkeley campus once.Quote:
Originally Posted by garyfromterrace
Well done Mofro.
This was absolutely amazing !!!! Those attitude jets seemed pretty serious.Quote:
Originally Posted by MultiVerse
So rad, congrats!Quote:
Originally Posted by Mofro261
Doc was after me to get on the Metformin for the high blood sugar OR Diabetes depending on if you are an old or new MDQuote:
Originally Posted by Gepeto
but my last a1C was pretty good so I kinda slide off her radar, so she quit bugging me
but she did ask if i was doing anything different so I suggested perhaps switching to IPA's from the pale ales
man moves Stonehenge like blocks by himself
https://www.youtube.com/watch?v=E5pZ7uR6v8c
The magnetic North Pole is on the move.
Magnetic North Pole moving in way never seen before by scientists