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To assess the sensitivity of the Mu variant to antibodies induced by SARS-CoV-2 infection and vaccination, we generated pseudoviruses harboring the spike proteins of Mu or the other VOC/VOIs. Virus neutralization assays revealed that the Mu variant is 12.4-fold more resistant to sera of eight COVID-19 convalescents, who were infected during the early pandemic (April–September, 2020), than the parental virus (P=0.0078; Figure 1B). Also, the Mu variant was 7.6-fold more resistant to sera obtained from ten BNT162b2-vaccinated individuals compared to the parental virus (P=0.0020; Figure 1C). Notably, although the Beta VOC was thought to be the most resistant variant to date,3,4 Mu pseudoviruses were significantly more resistant to convalescent serum-mediated neutralization than Beta pseudoviruses (P=0.031; Figure 1B).