Where can I buy DZX?
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Where can I buy DZX?
Appears to be Rx only: https://en.wikipedia.org/wiki/Diazoxide
Regardless, I definitely wouldn't mess with it if I wasn't obese and under strict medical supervision. I'd really like to read the full text of the study to see what kind of precautions they took to prevent adverse consequences of insulin suppression (at a minimum, I'd imagine these would be similar to Type 1 diabetes and include hyperglycemia and ketoacidosis). Messing with such a critically important hormone is not something to be taken lightly. For the non-obese (patients in the study had BMIs of 30-38) improving your insulin sensitivity and lowering your insulin production the old fashioned way through diet and exercise would carry a lot less risk (read: none).
Tomorrow I am taking the day off to go on a huge mountain bike ride, to see some aspens.
I am excited because mt biking. But I am a little nervous because the ride I'm planning is bigger than any I have done this year. And with the keto diet, I am new to managing food intake on a big exercise day like this. I have grown quite accustomed to not eating anything before/during exercise, I just stick with my normal eating schedule. And for 2+ hour rides, I drink a gatorade 30-60 minutes before starting (maybe 35g carbs). This works really well. But this ride might be 5 hours, and I'm not sure what to do. Will my body happily burn fat (ketones) while also using the gatorade? Should I bring a second gatorade for energy boost midway (yes)? Should I bring real food and try a whole different approach?
I am probably going to just bring the extra gatorade and also bring some keto foods (almonds, beef stick, etc). And I am excited to try out this notion of not needing any food for big exercise. But like I said, also nervous.
Gatorade will give more of the quick spike type energy that I would think is against what you are trying to do? Maybe stash one in pack if nervous. I would try the whole food route personally.
Well, quick spike is what I need. A few months ago I discovered that when exercising, I was fine with basic aerobic activity (jogging, gravel road grinds, etc) but when quick anaerobic bursts were needed, I was out of gas right from the start. After researching, I discovered that this was a common problem, that the anaerobic bursts don't come from ketones. I came upon what some call the "targeted keto" approach, which is to have 25-50g carbs about 30-60 minutes before that type of exercise (through trial and error I discovered that gatorade worked very well for this). Adopting this approach worked wonders, I had a couple of friends that rode with me before and after note that it was night and day how much faster I was.Quote:
Originally Posted by SkiBall
So I fully intend to drink the pre-ride gatorade, it's the mid-ride one I am not sure about, and mid-ride fueling in general that I am nervous about.
20-40 grams carbs/hour, depending on pace and how you're feeling. Gatorade is decidedly sub-optimal. Liquid Gatorade you buy off the shelf is sweetened with HCFS, which is 55% fructose. Fructose is a poor energy source for exercise since it can only be metabolized in the liver; unlike glucose your muscles cannot use it directly for energy. Fructose in more than minimal amounts is also known to cause gastric distress during endurance exercise. If you make it from a powder that's better, since sweetness in the powdered form comes from dextrose (glucose monosaccharide). But, glucose polysaccharides (starch, maltodextrin) are preferable to monosaccharides since they are absorbed in more concentrated solutions (~20% vs <10%). IOW, the ratio of grams of glucose absorbed to grams of water absorbed is higher, providing more energy and reducing the probability of gastric distress.
Get in some BCAAs or protein to prevent muscle catabolism.
Caffeine is a hell of a PED. Depending on your body size and personal tolerance, 50-100 mg every 2-3 hours.
Some reading:
https://www.hammernutrition.com/know...ial-knowledge/
https://www.hammernutrition.com/know...ced-knowledge/
You sure about gatorade being HFCS? Because I heard the things you claim re fructose and settled on gatorade after a) reading recommendations for it and b) looking at the nutrition label. http://www.pepsicobeveragefacts.com/...rm=RTD&size=20 Says "sugar" and "dextrose".
Try something like thisQuote:
Originally Posted by Danno
https://cdn8.bigcommerce.com/s-3453f...=2&imbypass=on
or this
https://cdn.shopify.com/s/files/1/11...g?v=1525721783
It used to be HFCS, they must have phased it out. I haven't actually drank it in a long time. Regardless:Quote:
Originally Posted by Danno
1. "Sugar" is the first ingredient after water. In this context, sugar = sucrose = 50/50 glucose/fructose. It's still a lot of fructose.
2. It's still entirely mono/disaccharides. Polysaccharides are far preferable.
Well, maybe I'll look for an alternative after I finish the big pack of gatorade I got at costco. :) I have heard to avoid fructose for the reason you mention, the other stuff you mention is new.
While this is my first big ride post-keto, it's not my first ride, so I'm not going to completely change up what I am doing. One of the reasons I started using gatorade is because I was having some stomach distress with my first choice of carbs (honey stinger waffles).
Only if I'm about to die.Quote:
Originally Posted by I've seen black diamonds!
Sciendentritionists- any issues you see with NUUN hydration / electrolyte tablets?
https://nuunlife.com/products/nuun-electrolytes/
I'm barely a dental hygienist, but I have used Nuun and it seemed to work. In the sense that playing two days of ultimate in 100+ degree heat in Phoenix would seem to require some form of electrolyte and that's all I used, and felt fine.
I use these for long rides; they seem to work. Not as much scaly residue in my bottles as Hammer Fizz, which is nice.Quote:
Originally Posted by Self Jupiter
Then why not use the Nuun and give the gatorade to the neighborhood kids? It would be a nice gesture.
are you asking me? if so, because I'm actually drinking the gatorade for the sugar, not the electrolytes. I use Ultima for pure eletcrolytes. https://www.ultimareplenisher.com/products/Quote:
Originally Posted by SkiBall
Most Nuun is for hydration/ electrolyte replacement. Low calorie. Some also have caffeine. They also make a higher calorie version (called "Performance" I think?) that is similar to Tailwind and other such products. I like the taste of the Nuun stuff better (it has less flavor), but it can be hard to find and doesn't dissolve very well. Some people also just squeeze a Gu (or similar) into a bottle and swish is it around until it sort of dissolves. Whatever works and offends your tastebuds the least. If you're not going to be out for a long time, or you take some breaks to chill and eat it's all unnecessary. Have a sandwich.
As a lifelong sugar addict, I am finally rebelling...mostly. I still have weakness...except when I am trying to do something healthy.Quote:
Originally Posted by Danno
i am not a fan of that nuun bc all the flavors have that fizzy/effervescence thing going on
orange gatorade is one of my favorite things in the world- I keep trying to find a similar/ better replacement but have not yet succeeded
Also tried those concentrated liquid Mio things and those were pretty good. lots of different flavors and some with electrolytes, caffeine etc
pretty sure they are filled with weird chemies but sometimes you just gotta flavor your water with something amirite
Skratch labs?
ON Amino Energy tastes good and will get you going.
I dig the skratch labs too. kinda spendy but good flavors
I actually just saw the skratch matcha flavor (w/ caffeine) half off on steep and cheap and that is a pretty god flavor too- iced tea like
https://www.steepandcheap.com/skratc...I6c2tyYXRjaA==
I drink some Gatorade zero. It may not be the best, but it feels good.
Godspeed amigo. Enjoy the ride.
I like Nuun, but it is kinda annoying with the "plop plop fizz fizz" thing. My water bottle squeals the whole way up the hill. Thought it was a leaky tire for a while. It is way better on my stomach than a lot of others are.Quote:
Originally Posted by b-bear
http://www.mdpi.com/2072-6643/10/9/1237
"In summary, our results based on a 12-week prospective study provide evidence that moderate intake of beer (traditional and alcohol-free) does not exert vascular detrimental effects nor increases body weight in obese healthy individuals. In contrast, moderate intake of beer increases the anti-oxidative properties of HDL and facilitates cholesterol efflux, which may prevent lipid deposition in the vessel wall."
https://www.thelancet.com/journals/l...812-9/fulltext
"Dairy consumption was associated with lower risk of mortality and major cardiovascular disease events in a diverse multinational cohort."
http://www.mdpi.com/2072-6643/10/9/1272
"These results suggest that the dietary cholesterol in whole egg was not well absorbed, which may provide mechanistic insight for why it does not acutely influence plasma total-cholesterol concentration and is not associated with longer-term plasma cholesterol control."
question for the nutrition folks- I've been trying to swill a tablespoon or so of ACV daily, but alone it makes me want to retch so I've been doing in a glass of cran juice (half juice/ half water maybe sometimes a lemon squeeze)
I'd like to take it in the morning, but am not digging the thought of that huge sugar spike from the juice, so have been doing afternoons
How do you guys take your acv- timing and masking flavor?
or maybe I just need to man up and look at it like a shot in the morning. breath out, take it down
Suck it up buttercup. Shoot it and chase w/ water. It gets better.
Perhaps just stop doing it? While it appears there may be modest benefits, probably not the pure-fucking-magic that the internet makes it out to be.Quote:
Originally Posted by b-bear
https://www.uchicagomedicine.org/hea...-cider-vinegar
Life's too short to force yourself to eat/drink shit that makes you retch.
:D
I haven't taken it in a while, but I would mix it in a glass of water and chug in the morning. Lately as a somewhat alternative, I've been eating lots of pickled and fermented foods.
This is what I do. 1 Tbs in a shot glass followed by two full shot glasses of water and my VitD pill. If you want to sweeten it up, avoid sugar, and do something else healthy for yourself, dissolve 1 Tbs glycine in several Tbs boiling water then add in the ACV. Tastes like tart hot apple cider. On the sweet-healthy matrix glycine is far upper right.Quote:
Originally Posted by b-bear
There is semi-ridiculous hype surrounding ACV. That said, it is very soundly established that acetic acid significantly improves insulin sensitivity and blood sugar control in healthy, prediabetic and diabetic people. In that sense ACV is definitely nothing magical, any vinegar works even distilled white. ACV does happen to taste better, and the Bragg organic stuff makes great whiskey cocktails.Quote:
Originally Posted by skaredshtles
Chronic mild to moderate insulin resistance, hyperinsulinemia and hyperglycemia are no joke. Here's the results from the study the article linked to. It was a small study, but these results have been reliably replicated in many other studies.
Attachment 247976
Even in the healthy subjects achieved a nearly 50% lower blood sugar spike while producing ~30% less insulin. That. Is. Huge. The results from the insulin-resistant group were even more dramatic. There is no drug I'm aware of that remotely compares to these results.
No acetic acid in lactic-fermented foods.Quote:
Originally Posted by Danno
Dan, Any thoughts on NAD+?
ACV started burning my esophagus. Probably not great to drink it straight.
Definitely want to chase it with water immediately if you're drinking it straight up.Quote:
Originally Posted by shredgnar
Sort of like parabiosis, the in vitro and animal data is very promising but AFAIK there is a total lack of human trials. It seems unlikely that nicotinamide riboside supplements will turn out to be unhealthy, but they're not cheap so there's a decent chance your just pissing money away. They probably don't do anything if your natural NAD+ production hasn't fallen off a lot which I think doesn't really happen until after 40.Quote:
Originally Posted by shredgnar
If I were 40+ and had money to burn I'd definitely consider it alongside mild HGH/Test supplementation. It's all pissing into the wind though if you're not already eating healthy, minimizing your sedentary time and lifting heavy shit and sprinting regularly.
Does sprinting across a crowded street on my bike count? I do that almost daily. :D
ACV straight up. You get used to it, then you start tasting the differences in the batches of Bragg, and the sweetness that develops as it gets older. I don't drink it religiously, but it's awesome for occasional heartburn, and I try to remember to swig some on crappy eating days. Mornings are tough because I typically don't eat breakfast, and my empty tummy doesn't love straight vinegar.
Indeed! Usually at least once a day I end up going balls out for 10-20 seconds trying to catch a green light on my commute. Anything that activates your Type IIB muscle fibers is gravy.Quote:
Originally Posted by bagtagley
mmmm gravy
A gut-brain neural circuit for nutrient sensory transduction
(edit- more user friendly synopsis here- https://www.eurekalert.org/pub_relea...u-si091718.php)
CONCLUSION:
We identified a type of gut sensory epithelial cell that synapses with vagal neurons. This cell has been referred to as the gut endocrine cell, but its ability to form a neuroepithelial circuit calls for a new name. We term this gut epithelial cell that forms synapses the neuropod cell. By synapsing with the vagus nerve, neuropod cells connect the gut lumen to the brainstem. Neuropod cells transduce sensory stimuli from sugars in milliseconds by using glutamate as a neurotransmitter. The neural circuit they form gives the gut the rapidity to tell the brain of all the occurrences of the day, so that he, too, can make sense of what we eat.
Do tell, recipes? We have a huge bottle my wife had been taking but has since fallen off the wagon. I mean, if you can mix it with whiskey than maybe it's not just hype?Quote:
Originally Posted by Dantheman
This is pretty fucking cool.Quote:
Originally Posted by Mofro261
it's gut vs mouth/taste, but I wonder if similar circuits are involved when athletes just swishing and spitting out a sports drink can still trigger performance response as if they'd swallowed the carbs
Whoa.Quote:
Originally Posted by Mofro261
A couple I like:Quote:
Originally Posted by Joey Joe Joe Junior Shabadoo
3:1:0.5-1 Whiskey, homemade ginger syrup, Bragg. Start with half a part Bragg, add more if you want to up the vinegar flavor. A few drops of lemon juice rounds out the acid profile nicely.
Or, same ratios, but swap the ginger syrup for Citronge.